Description
Product Characteristics:
Aliases: epididymis secretory sperm binding protein Li 96n antibody, HEL-S-96n antibody, HYA1 antibody, HYAL PH-20 antibody, HYAL PH20 antibody, Hyal-PH20 antibody, HYAL1 antibody, HYAL3 antibody, HYAL5 antibody, HYALP_HUMAN antibody, Hyaluronidase PH-20 antibody, Hyaluronoglucosaminidase PH-20 antibody, MGC26532 antibody, PH-20 Hyaluronidase antibody, PH20 antibody, PH20 Hyaluronidase antibody, SPAG15 antibody, SPAM-1 antibody, Spam1 antibody, sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) antibody, Sperm adhesion molecule 1 antibody, Sperm surface protein PH-20 antibody, Sperm surface protein PH20 antibody, zona pellucida binding antibody
Target Information: Hyaluronidase degrades hyaluronic acid, a major structural proteoglycan found in extracellular matrices and basement membranes. Six members of the hyaluronidase family are clustered into two tightly linked groups on chromosome 3p21.3 and 7q31.3. This gene was previously referred to as HYAL1 and HYA1 and has since been assigned the official symbol SPAM1\, another family member on chromosome 3p21.3 has been assigned HYAL1. This gene encodes a GPI-anchored enzyme located on the human sperm surface and inner acrosomal membrane. This multifunctional protein is a hyaluronidase that enables sperm to penetrate through the hyaluronic acid-rich cumulus cell layer surrounding the oocyte, a receptor that plays a role in hyaluronic acid induced cell signaling, and a receptor that is involved in sperm-zona pellucida adhesion. Abnormal expression of this gene in tumors has implicated this protein in degradation of basement membranes leading to tumor invasion and metastasis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]